111年度行政院農委會實地查核,本院動物實驗中心評比結果為『優』
動物科學應用機構定期接受行政院農業委員會查核,農委會邀集直轄市或縣(市)政府動物保護檢查員、實驗動物相關學者、專家、相關機關及立案之動物保護團體代表組成查核小組,以書面或實地查核方式,執行動物科學應用機構之查核。
研究主題及技術服務平台
動物中心本著服務為主軸,提供動物飼育與管理。配合國際相關法規,每年舉辦研究人員飼育管理技術課程。本中心配合動物 保護法之相關規定成立實驗動物照護及管理委員會,所有動物實驗計劃均須經此委員會同意後方得進行,以確保動物福祉。
本中心實驗動物種類繁多,包括囓齒類、倉鼠、天竺鼠、兔子、豬及斑馬魚。使用這些動物進行的研究計劃。主要研究有癌症、糖尿 病、高血壓、基因治療、腎臟疾病、藥理、免疫、中草藥、藥物動力學、骨科、眼科等。 近年來已成功建立基因轉殖技術平台,包含動物品種為囓齒類及斑馬魚。
動物疾病模式建立:原發性肝癌、心臟血管支架置放、高膽固醇高血脂、急慢性腎臟衰竭、高血壓、骨質疏鬆症、第一型糖尿病、 心肌梗塞、視網膜局部缺血、關節炎之動物模式、活體之幹細胞抽取。
代表著作
- Chen SJ, Wang SC, Chen YC. Challenges, recent advances and perspectives in the treatment of human cytomegalovirus infections. Tropical Medicine and Infectious Disease 2022; 7(12):439. (SCIE, PARASITOLOGY) (IF: 3.711, Ranking: 11/39=28.2%)
- Chen SJ, Wang SC, Chen YC. The immunotherapy for colorectal cancer, lung cancer and pancreatic cancer. International Journal of Molecular Sciences 2021; 22(23):12836. (SCIE, BIOCHEMISTRY & MOLECULAR BIOLOGY) (IF: 6.208, Ranking: 69/297=23.2%)
- Chen SJ, Lin TB, Peng HY, Lin CH, Lee AS, Liu HJ, Li CC, Tseng KW. Protective effects of fucoxanthin dampen pathogen-associated molecular pattern (PAMP) lipopolysaccharide-induced inflammatory action and elevated intraocular pressure by activating Nrf2 signaling and generating reactive oxygen species. Antioxidants 2021; 10(7):1092. (SCIE, CHEMISTRY, MEDICINAL) (IF: 7.675, Ranking: 4/63=6.3%)
- Chen SJ, Lin TB, Peng HY, Liu HJ, Lee AS, Lin CH, Tseng KW. Cytoprotective potential of fucoxanthin in oxidative stress-induced age-related macular degeneration and retinal pigment epithelial cell senescence in vivo and in vitro. Marine Drugs 2021; 19(2):114. (SCIE, CHEMISTRY, MEDICINAL) (IF: 6.085, Ranking: 10/63=15.8%)
- Chen SJ, Wang SC, Chen YC. Novel antiviral strategies in the treatment of COVID-19: A review. Microorganisms 2020; 8(9):1259. (SCIE, MICROBIOLOGY) (IF: 4.926, Ranking: 54/137=39.4%)
- Wang SC, Chen SJ, Chen YC. Potential therapeutic approaches against brain diseases associated with cytomegalovirus infections. International Journal of Molecular Sciences 2020; 21(4):1376. (SCIE, BIOCHEMISTRY & MOLECULAR BIOLOGY) (IF: 6.208, Ranking: 69/297=23.2%)