粒線體醫學研究組

組長   林達雄 醫師

研究人員

黃玉文 博士
吳竺燕、黃榮達、李宗翰、呂珮瑄

粒線體醫學研究組於2010年6月1日正式設立，設立宗旨在於 「探討粒線體在人類健康與疾病所扮演的角色」，了解粒線體功能尋找增進人類健康與壽命的方法。主要目標為(1)建立粒線體疾病診斷平台；(2)早老及遺傳疾病，病人粒線體功能之探討；(3)研究核DNA與粒線體DNA的互動調控；(4)建立粒線體疾病的疾病模式。希望藉此瞭解粒線體在健康及疾病上所扮演之角色，同時廣泛尋求國內外其他專業機構之合作，從而研發新藥物治癒疾病增進人類健康。

陽明交通大學
應用無線腦波於探討注意力不足過動症亞型之腦部動態差異

透過粒線體全基因定序、粒線體常見疾病之熱點快速診斷、粒線體大片斷缺失之篩檢、粒線體DNA套數分析、及粒線體相關之核基因分析等提供臨床醫師做臨床診斷之參考。另外，近三年來已發表多篇高點數SCIE期刊論文，並且已經利用誘導性多功能幹細胞（induced pluripotent stem cells）技術，建立粒線體疾病模式平台，為全台唯一將此平台運用於臨床疾病研究上的實驗室。

專利
Obese Zebrafish Model with Over Expression of Akt1 Enhances Adipogenesis (I 413693)
檢測人體核心溫度之系統及其方法 (I 650101)

獎項
第18屆國家新創獎精進續獎_2021年
第17屆國家新創獎_2020年

Lin DS*, Huang YW, Ho CS, Huang TS, Lee TH, Wu TY, Huang ZD, Wang TJ. Impact of mitochondrial A3243G heteroplasmy on mitochondrial bioenergetics and dynamics of directly reprogrammed MELAS neurons. Cells 2023; 12(1):15. (SCIE, CELL BIOLOGY) (IF: 7.666, Ranking: 51/195=26.1%)

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 2021; 1-382. (SCIE, CELL BIOLOGY) (IF: 13.391, Ranking: 22/195=23.1%) Towards a reference genome that captures global genetic diversity. Nature Communications 2020; 11(1):5482. (SCIE, Multidisciplinary Sciences) (IF: 17.694, Ranking: 6/74=8.1%) 

Lin DS*, Ho CS, Huang YW, Wu TY, Lee TH, Huang ZD, Wang TJ, Yang SJ, Chiang MF. Impairment of proteasome and autophagy underlying the pathogenesis of leukodystrophy. Cells 2020; 9(5):1124. (SCIE, CELL BIOLOGY) (IF: 7.666, Ranking: 51/195=26.1%) 

Liang ST, Audira G, Juniardi S, Chen J-R, Lai Y-H, Du ZC*, Lin DS*, Hsiao CD*. Zebrafish carrying pcyr1 gene deficiency display aging and multiple behavioral abnormalities. Cells 2019; 8(5):453. (SCIE, CELL BIOLOGY) (IF: 4.342, Ranking: 13/82=15.8%)

Lin DS*, Huang YW, Ho CS, Hung PL, Hsu MH, Wang TJ, Wu TY, Lee TH, Huang ZD, Chang PC, Chiang MF*. Oxidative insults and mitochondrial DNA mutation promote enhanced autophagy and mitophagy compromising cell viability in pluripotent cell model of mitochondrial disease. Cells 2019; 8(1):65. (SCIE, CELL BIOLOGY) (IF: 4.342, Ranking: 13/82=15.8%)

Huang YW, Chiang MF, Ho CS, Hung PL, Hsu MH, Lee TH, Chu JL, Liu H, Tang P, Ng VW*, Lin DS*. A transcriptome study of progeroid neurocutaneous syndrome reveals POSTN as a new element in proline metabolic disorder. Aging and Disease 2018; 9(6):1043-1057. (SCIE, GERIATRICS & GERONTOLOGY) (IF: 9.968, Ranking: 5/54=9.2%)

Chikara RK, Chang EC, Lu YC, Lin DS, Lin CT, Ko LW*. Monetary reward and punishment to response inhibition modulate activation and synchronization within the inhibitory brain network. Frontiers in Human Neuroscience 2018; 12:27. (SCIE, NEUROSCIENCES) (IF: 3.473, Ranking: 163/275=59.2%)

Liu LH, Lin SM, Lin DS, Chen MR. Losartan in combination with propranolol slows the aortic root dilatation in neonatal Marfan syndrom. Pediatrics & Neonatology 2018; 59(2):211-213. (SCIE, PEDIATRICS) (IF: 2.586, Ranking: 67/130=51.5%)