免疫基因研究組

研究員：許淳欣 博士

研究人員 ：李慧玲、陳立揚、陳品龍

進駐研究醫師：重症醫療科-劉彥佑，骨科-陳暐錚，胸腔內科-鍾心珮

合作單位：
台東馬偕
  心臟內科-王光德、趙川磊
健檢中心主任-吳佳憲

  醫事檢驗科-廖秋珠、郭美杏
臺北市立大學運動學院：曾國維、曾暐晉、陳永盛

研究米田堡血型表現在循環生理、呼吸生理及運動生理上的角色與機轉。

研究NMDA receptor自體免疫腦炎及檢驗方法之改良。

與HLA相關疾病研究。

血小板、顆粒球自體抗體研究。

先天性顆粒球缺乏症研究。

A simple determination of Miltenberger blood group antigen Mi.III by PCR. (Taiwan Invention Patent No. I437229; effective from 2014/05/11 to 2031/11/10) 。

NMDA receptor自體抗體檢驗改良。

HLA高解析核酸序列分型及抗體鑑定。

血小板特異抗原(HPA)分型及抗體鑑定。

顆粒球特異抗原(HNA)分型及抗體鑑定。

利用專利之PCR分型技術，已完成東南亞族群GP.Mur(MiIII)頻率分佈研究。

米田堡血型蛋白相關的生化與生理研究。

已完成HLA-A、B、C、DRB1、DQB1及DPB1等基因座的核酸定序分型法(Sequence-based typing, SBT)之建立，在常規分型有疑異時提供高解析分型，也因此陸續發現多個新對偶基因型存在於台灣族群中。

已完成血小板抗原系統(HPA-1,2,3,4,5,15)在台灣族群中抗原分佈情形。

已完成與捐血中心合作調查血小板CD36缺乏、嗜中性白血球抗原系統在台灣的分佈情形，並建立以DNA為基礎的分型及異體抗體偵測的技術。

Hsu K. Differential enzymatic deglycosylation reveals attachment of red cell B antigen onto the carbohydrate moiety of glycophorin A and glycophorin B. Vox Sanguinis 2023; 118(2):147-152. (SCIE, HEMATOLOGY) (IF: 2.996, Ranking: 53/78=67.9%)

Hsu K, Tseng WC. What decides your athletic career ? —Reflection from our study of GP.Mur-associated sports talents during the covid-19 pandemic era. International Journal of Environmental Research and Public Health 2022; 19(19):12691. (SCIE, ENVIRONMENTAL SCIENCES) (IF: 4.614, Ranking: 85/325=26.2%)

Chen YC, Hsu KN, Lai CY, Chen LT, Kuo MS, Liao CC, Hsu K. Influence of hemoglobin on blood pressure among people with GP.Mur blood type. Journal of the Formosan Medical Association 2022; 121(9):1721-1727. (SCIE, MEDICINE, GENERAL & INTERNAL) (IF: 3.871, Ranking: 56/329=17.0%) 

Kuo MS, Chuang CH, Cheng HC, Lin HR, Wang JS, Hsu K. Different involvement of band 3 in red cell deformability and osmotic fragility-A comparative GP.Mur erythrocyte study. Cells 2021; 10:3369. (SCIE, CELL BIOLOGY) (IF: 7.666, Ranking: 51/195=26.2%)

Hsu K, Liu YY, Tseng WC, Huang KT, Liu CY, Chen LY, Lee HL, Lin HJ, Tseng KW, Yeh HI. Comodulation of no-dependent vasodilation by erythroid band 3 and hemoglobin: A GP.Mur athlete study. Frontiers in Cardiovascular Medicine 2021; 8:740100. (SCIE, CARDIAC & CARDIOVASCULAR SYSTEMS) (IF: 5.848, Ranking: 59/208=28.4%)

Chang YC, Chiang YH, Hsu K, Chuang CK, Kao CW, Chang YF, Chang MC, Lim KH, Cheng HI, Hsu YN, Chen CG. Activated naïve γδ T cells accelerate deep molecular response to BCR-ABL inhibitors in patients with chronic myeloid leukemia. Blood Cancer Journal 2021; 11:182. (SCIE, ONCOLOGY) (IF: 9.812, Ranking: 34/318=10.7%)

Lim KH, Chen LC, Hsu K, Chang CC, Chang CY, Kao CW, Chang YF, Chang MC, Chen CG. BAFF-driven NLRP3 inflammasome activation in B cells. Cell Death and Disease 2020; 11:820. (SCIE, CELL BIOLOGY) (IF: 9.696, Ranking: 36/195=18.5%)

Lee YJ, Ting WH, Yang YW, Lin CJ, Hsieh YT, Huang CY, Lo FS, Chu CC, Lin CL, Lin WS, Lai TS. HLA-DQ genotype and biochemical characterization of anti-transglutaminase 2 antibodies in patients with type 1 diabetes mellitus in Taiwan. FASEB Journal 2020; 34(6):8459-8474. (SCIE, BIOLOGY) (IF: 5.834, Ranking: 16/94=17.0%)

Wang LY, Chen CF, Wu TW, Lai SK, Chu CC, Lin HH. Response to hepatitis B vaccination is co-determined by HLA-DPA1 and -DPB1. Vaccine 2019; 37(43):6435-6440. (SCIE, MEDICINE, RESEARCH & EXPERIMENTAL) (IF: 4.169, Ranking: 69/195=35.4%)