循環生理研究組

組長  吳懿哲 醫師

進駐研究醫師：
葉宏一、蘇正煌、洪崇烈
陳俊延、林肇鋒、劉彥佑

研究人員

李亦男 博士、謝姎紋 博士
田婷怡、周彥宏、謝金玲、張瓊尹
李欣怡、王博正、盧盈叡、楊勝勛

1. 肺高壓的致病機轉探討與新穎治療模式開發。

2. 系統性調查小分子核醣核酸在心血管疾病與老化過程中所扮演的角色及開發成生物標記。

3. 奈米金團簇在心血管疾病的轉譯醫學與作用機制的探討。

4. 心血管細胞的隙連結在健康與疾病狀態所扮演的角色。

1. 奈米金團簇生物效應

2. 超音波微氣泡傳送非病毒載體基因

3. 細胞粒線體功能分析

4. 心臟電生理研究

奈米金團簇經由試管內及活體內研究，驗證其具有極佳之生物相容性，並且在動物模式發現奈米金團簇具有抗氧化力與抗發炎效果，並取得相關專利。

Use of gold nanoclusters in ameliorating oxidative stress and/or aging (US9,101,672B2)

Evaluation system or determination of cardiovascular function parameters (I528945) Use of peptide for treating angiogenesis-related diseases (US 9925238 B2)

Aurantiamide dipeptide derivatives for treatment or prevention of angiogenesis-related diseases (US 9,872,882 B2)

Array-Type-Transducer-based High-Power Ultrasound Delivery System (US 8,624,207 B2)

Tien TY, Wu YJ, Su CH, Wang HH, Hsieh CL, Wang BJ, Su Y, Yeh HI*. Reduction of connexin 43 attenuates angiogenic effects of human smooth muscle progenitor cells via inactivation of AKT and NF-ΚB pathway. Arteriosclerosis, Thrombosis, and Vascular Biology. 2021; 41(2):915-930. (SCIE, PERIPHERAL VASCULAR DISEASE) (IF: 10.514, Ranking: 5/67=93.28%)

Lee YN, Wu YJ, Lee HI, Wang HH, Chang CY, Tien TY, Lin CF, Su CH*, Yeh HI. Ultrasonic microbubble VEGF gene delivery improves angiogenesis of senescent endothelial progenitor cells. Scientific Reports 2021; 11(1):13449. (SCIE, MULTIDISCIPLINARY SCIENCES) (IF: 4.997, Ranking: 19/74=75%) 

Wang HH, Lin CJ, Tseng YM, Lee HI, Lee YN, Yeh HI, Yang PS, Peng HY, Wu YJ*. Dihydrolipoic acid- coated gold nanocluster bioactivity against senescence and inflammation through the mitochondria-mediated JNK/AP-1 pathway. Nanomedicine 2021; 36:102427. (SCIE, BIOTECHNOLOGY & APPLIED MICROBIOLOGY) (IF: 6.096, Ranking: 31/159=80.82%)

Lee YN, Wang HH, Su CH, Lee HI, Chou YH, Hsieh CL, Liu WT, Shu KT, Chang KT, Yeh HI, Wu YJ*. Deferoxamine accelerates endothelial progenitor cell senescence to compromise angiogenic activity. Aging (Albany NY) 2021; 13(17):21364-21384. (SCIE, GERIATRICS & GERONTOLOGY) (IF: 5.955, Ranking: 15/54=73.15%)

Wang HH, Lee YN, Su CH, Shu KT, Liu WT, Hsieh CL, Yeh HI, Wu YJ*. S-phase kinase-associated protein-2 rejuvenates senescent endothelial progenitor cells and induces angiogenesis in vivo. Scientific Reports 2020; 10(1):6646. (SCIE, MULTIDISCIPLINARY SCIENCES) (IF: 4.997, Ranking: 19/74=75%)

Wang HH, Wu YJ, Tseng YM, Su CH, Hsieh CL, Yeh HI. Mitochondrial fission protein 1 up-regulation ameliorates senescence-related endothelial dysfunction of human endothelial progenitor cells. Angiogenesis 2019; 22(4):569-582. (SCIE, PERIPHERAL VASCULAR DISEASE) (IF: 10.658, Ranking: 4/67=94.78%)