循環生理研究組

組長  吳懿哲 醫師

進駐研究醫師：
葉宏一、蘇正煌、洪崇烈、陳俊延、林肇鋒、劉彥佑

研究人員

李亦男 博士
田婷怡 博士
謝姎紋 博士
周彥宏、謝金玲、張瓊尹、李欣怡、王博正、盧盈叡、楊勝勛

肺高壓的致病機轉探討與新穎治療模式開發。

系統性調查小分子核醣核酸在心血管疾病與老化過程中所扮演的角色及開發成生物標記。

奈米金團簇在心血管疾病的轉譯醫學與作用機制的探討。

心血管細胞的隙連結在健康與疾病狀態所扮演的角色。

奈米金團簇生物效應

超音波微氣泡傳送非病毒載體基因

細胞粒線體功能分析

心臟電生理研究

奈米金團簇經由試管內及活體內研究，驗證其具有極佳之生物相容性，並且在動物模式發現奈米金團簇具有抗氧化力與抗發炎效果，並取得相關專利。

Use of gold nanoclusters in ameliorating oxidative stress and/or aging (US9,101,672B2)

Evaluation system or determination of cardiovascular function parameters (I528945) Use of peptide for treating angiogenesis-related diseases (US 9925238 B2)

Use of gold nanoclusters in treating hypercholesterolemia or hypercholesterolemia-associated diseases (patent #I756537, Taiwan)

Aurantiamide dipeptide derivatives for treatment or prevention of angiogenesis-related diseases (US 9,872,882 B2)

Array-Type-Transducer-based High-Power Ultrasound Delivery System (US 8,624,207 B2)

Confocal laser scanning microscopy
Cellular micro-injecter
Ultrasound gene transfer
Catheterization laboratory
Small animal echocardiogram
Small animal ECG monitor。

Lee YN, Wu YJ, Su CH, Wang BJ, Yang SH, Lee HI, Chou YH, Tien TY, Lin CF, Chan WH, Chung CH, Wang SW, Yeh HI. Fluorescent gold nanoclusters possess multiple actions against atherosclerosis. Redox Biology 2024; 78:103427. (SCIE, BIOCHEMISTRY & MOLECULAR BIOLOGY) (IF: 10.7, Ranking=17/313=5.4%)

Chou YH, Lee YN, Su CH, Lee HI, Hsieh CL, Tien TY, Lin CF, Yeh HI, Wu YJ. Senescence induces miR-409 to down-regulate CCL5 and impairs angiogenesis in endothelial progenitor cells. Journal of Cellular and Molecular Medicine 2024; 28(12):e18489. (SCIE, MEDICINE, RESEARCH & EXPERIMENTAL) (IF: 4.3, Ranking=58/198=29.3%)

Tien TY, Wu YJ, Chang CY, Hung CL, Lee YN, Lee HI, Chou YH, Lin CF, Lee CW, Su CH, Yeh HI. Hsa-miR-134-5p predicts cardiovascular risk in circulating mononuclear cells and improves angiogenic action of senescent endothelial progenitor cells. Journal of Cellular and Molecular Medicine 2024; 28(13):e18523. (SCIE, MEDICINE, RESEARCH & EXPERIMENTAL) (IF: 4.3, Ranking=58/198=29.3%)

Lee, YN, Wu YJ, Lee HI, Wang HH, Hung CL, Chang CY, Chou YH, Tien TY, Lee CW, Lin CF, Su CH, Yeh HI. Hsa-miR-409-3p regulates endothelial progenitor senescence via PP2A-P38 and is a potential ageing marker in humans. Journal of Cellular and Molecular Medicine 2023; 27(5):687-700. (SCIE, MEDICINE, RESEARCH & EXPERIMENTAL) (IF: 4.3, Ranking=58/198=29.8%)

Tien TY, Wu YJ, Su CH, Hsieh CL, Wang BJ, Lee YN, Su Y, Yeh HI. Pannexin 1 modulates angiogenic activities of human endothelial colony-forming cells through IGF-1 mechanism and is a marker of senescence. Arteriosclerosis, Thrombosis, and Vascular Biology 2023; 43(10):1935-1951. (SCIE, PERIPHERAL VASCULAR DISEASE) (IF: 7.4, Ranking=5/96=5.2%)

Tien TY, Wu YJ, Su CH, Wang HH, Hsieh CL, Wang BJ, Su Y, Yeh HI. Reduction of connexin 43 attenuates angiogenic effects of human smooth muscle progenitor cells via inactivation of Akt and NF-κB pathway. Arteriosclerosis, Thrombosis, and Vascular Biology 2021; 41(2):915-930. (SCIE, PERIPHERAL VASCULAR DISEASE) (IF: 10.514, Ranking=5/67=7.5%)

Lee YN, Wu YJ, Lee HI, Wang HH, Chang CY, Tien TY, Lin CF, Su CH, Yeh HI. Ultrasonic microbubble VEGF gene delivery improves angiogenesis of senescent endothelial progenitor cells. Scientific Reports 2021;11(1):13449. (SCIE, MULTIDISCIPLINARY SCIENCES) (IF: 4.997, Ranking=19/74=25.7%)

Wang HH, Lin CA, Tseng YM, Lee HI, Lee YN, Yeh HI, Yang PS, Peng HY, Wu YJ. Dihydrolipoic acid-coated gold nanocluster bioactivity against senescence and inflammation through the mitochondria-mediated JNK/AP-1 pathway. Nanomedicine 2021; 36:102427. (SCIE, BIOTECHNOLOGY & APPLIED MICROBIOLOGY) (IF: 6.096, Ranking=31/159=19.5%)

Lee YN, Wang HH, Su CH, Lee HI, Chou YH, Hsieh CL, Liu WT, Shu KT, Chang KT, Yeh HI, Wu YJ. Deferoxamine accelerates endothelial progenitor cell senescence to compromise angiogenic activity. Aging 2021; 13(17):21364-21384. (SCIE, GERIATRICS & GERONTOLOGY) (IF: 5.955, Ranking=15/54=27.8%)

Wang HH, Lee YN, Su CH, Shu KT, Liu WT, Hsieh CL, Yeh HI, Wu YJ. S-phase kinase-associated protein-2 rejuvenates senescent endothelial progenitor cells and induces angiogenesis in vivo. Scientific reports 2020; 10(1):6646. (SCIE, MULTIDISCIPLINARY SCIENCES) (IF: 4.38, Ranking=17/72=23.6%)