共同實驗室(六)

組長   劉家源 醫師、 林俊昌 醫師

進駐研究醫師：
兒科部 李宏昌
心臟內科 洪崇烈
胃腸肝膽科 張經緯、賴建翰
中醫部 李以荍

研究人員

江謝正雄 博士
廖淑芳、李俐慧、張鳳婷、鄭美蓮

運用NGS技術進行腸道菌相的相關研究。

使用益生菌(Probiotics)及各種改良式微菌叢植入(Fecal Microbiota Transplantation)，進行相關疾病的療效及可能機轉研究。

運用大腸癌植入小鼠，接受5-FU/FOLFOX後產生化學治療引發腹瀉之動物模型，接受各種治療，進行發炎、增生及細胞凋亡等途徑之機制研究。

建立飲食誘發肥胖脂肪肝模型，產生具有類似代謝症候群的小鼠動物模式，以評估代謝及脂肪肝相關疾病（如心血管疾病）之致病機轉與可能途徑。

肝臟腫瘤之病人雖經根治性之治療(開刀切除、射頻燒灼、肝臟移植)，仍有不少病人面臨腫瘤復發或轉移之困擾，近年雖有標靶治療藥物及免疫治療，但臨床治療成績仍不夠理想，如能找出肝臟腫瘤之復發與轉移機轉，將對廣大的肝臟腫瘤族群提供很大的幫助。目前已建立肝臟腫瘤病人檢體組織陣列，將繼續以免疫組織染色方法染肝臟腫瘤病人檢體組織陣列，研究可能造成肝癌復發及轉移之因子。

Hung CL, Sung KT, Chang SC, Liu YY, Kuo JY, Huang WH, Su CH, Liu CC, Tsai SY, Liu CY, Lee AS, Pan SH, Wang SW, Hou CJ, Hung TC, Yeh HI. Variant aldehyde dehydrogenase 2 (ALDH2*2) as a risk factor for mechanical LA substrate formation and atrial fibrillation with modest alcohol consumption in ethnic asians. Biomolecules 2021; 11(11):1559. (SCIE, BIOCHEMISTRY & MOLECULAR BIOLOGY) (IF: 6.064, Ranking: 75/297=25.3%)

Yeung CY, Chiang Chiau JS, Cheng ML, Chan WT, Jiang CB, Chang SW, Liu CY, Chang CW, Lee HC. Effects of vitamin D-deficient diet on intestinal epithelial integrity and Zonulin expression in a C57BL/6 mouse model. Front Med (Lausanne) 2021; 8:649818. (SCIE, MEDICINE, GENERAL & INTERNAL) (IF: 5.058, Ranking: 53/172=30.8%)

Chang CW, Lee HC, Li LH, Chiang Chiau JS, Wang TE, Chuang WH, Chen MJ, Wang HY, Shih SC, Liu CY*, Tsai TH, Chen YJ. Fecal microbiota transplantation prevents intestinal injury, upregulation of Toll-Like receptors, and 5-fluorouracil/oxaliplatin-induced toxicity in colorectal cancer. International Journal of Molecular Sciences 2020; 21(2):386. (SCIE, BIOCHEMISTRY & MOLECULAR BIOLOGY) (IF: 6.208, Ranking: 69/297=23.2%) (Co-corresponding author)

Chung IC, OuYang CN, Yuan SN, Lin HC, Huang KY, Wu PS, Liu CY, Tsai KJ, Loi LK, Chen YJ, Chung AK, Ojcius DM, Chang YS, Chen LC. Pretreatment with a heat-killed probiotic modulates the NLRP3 inflammasome and attenuates colitis-associated colorectal cancer in mice. Nutrients 2019; 11(3):516. (SCIE, NUTRITION & DIETETICS) (IF: 6.706, Ranking: 15/90=16.7%)

Chang CW, Liu CY, Lee HC, Huang YH, Li LH, Chiau JC, Wang TE, Chu CH, Shih SC, Tsai TH, Chen YJ. Lactobacillus casei variety rhamnosus probiotic preventively attenuates 5-fluorouracil/oxaliplatin-induced intestinal injury in a syngeneic colorectal cancer model. Frontiers in Microbiology 2018; 9:983. (SCIE, MICROBIOLOGY) (IF: 6.064, Ranking: 34/137=24.8%)

Hung CL, Pan SH, Han CL, Chang CW, Hsu YL, Su CH, Shih SC, Lai YJ, Chiang Chiau JS, Yeh HI, Liu CY* Lee HC, Lam CSP. Membrane proteomics of impaired energetics and cytoskeletal disorganization in elderly diet-induced diabetic mice. Journal of Proteome Research 2017; 16(10):3504-3513. (SCIE, BIOCHEMICAL RESEARCH METHODS) (IF: 5.37, Ranking: 16/79=20.3%) (Co-corresponding author)

Liu CY, Chang CW, Lee HC, Chen YC, Tsai TH, Jen-Shiu CC, Wang TE, Tsai MC, Yeung CY, Shih SC. Metabolic damage presents differently in young and early-aged C57BL/6 mice fed a high-fat diet. International Journal of Gerontology 2016; 10(2):105-111. (SCIE, GERIATRICS & GERONTOLOGY) (IF: 0.358, Ranking: 54/54=100%)

 Lin JC, Liu TP, Andriani V, Athoillah M, Wang CY, Yang PM. Bioinformatics analysis identifies precision treatment with paclitaxel for hepatocellular carcinoma patients harboring mutant TP53 or wild-type CTNNB1 gene. Journal of Personalized Medicine 2021; 11(11):1199. (SCIE, HEALTH CARE SCIENCES & SERVICES) (IF: 3.508, Ranking: 42/109=38.5%)

Lin JC, Yang PM, Liu TP. PERK/ATF4-dependent ZFAS1 upregulation is associated with sorafenib resistance in hepatocellular carcinoma cells. International Journal of Molecular Sciences 2021; 22(11):5848. (SCIE, CHEMISTRY, MULTIDISCIPLINARY) (IF: 6.208, Ranking: 50/179=48.4%)

Lin JC, Liu CL, Chang YC, Cheng SP, Huang WC, Lin CH, Wu CY, Chen MJ. Trilostane, a 3β-hydroxysteroid dehydrogenase inhibitor, suppresses growth of hepatocellular carcinoma and enhances anti-cancer effects of sorafenib. Invest New Drugs 2021; 39(6):1493-1506. (SCIE, PHARMACOLOGY & PHARMACY) (IF: 3.651, Ranking: 135/279=48.4%)

Lin JC, Liu TP, Yang PM. CDKN2A-inactivated pancreatic ductal adenocarcinoma exhibits therapeutic sensitivity to paclitaxel: A bioinformatics study. Journal of Clinical Medicine 2020; 9(12):4019. (SCIE, MEDICINE, GENERAL & INTERNAL) (IF: 4.964, Ranking: 55/172=32.0%)

Lee CC, Lin JC, Hwang WL, Kuo YJ, Chen HK, Tai SK, Lin CC, Yang MH. Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization. Nature Communications 2018; 9(1):3763. (SCIE, MULTIDISCIPLINARY SCIENCES) (IF: 17.694, Ranking: 6/74=8.1%)