微生物研究組

組長   劉昌邦 醫師

進駐研究醫師：兒童感染科 紀鑫

研究人員

翁麗涓、王乃玉、馮柔安

成立生物材料資源保存中心，針對檢驗科所分離並鑑定完成的病原株，建制一套資訊化管理模式和訂定生物保全管理規範，可進一步提供臨床醫師於治療方面資訊之所需；並且給予有興趣的研究人員關於檢體樣本資訊之索引，將其推展到院內感染管制層面的實際需求及運用。實驗室之研究特色主要發展脈衝式電泳技術，將其應用於流行性感染疾病之檢測、物種親疏遠近關係之分析、院內群突發感染菌種之監測，建置與疾病管制署同一資訊平台，有利於日後相關資料的比對和確認。病毒研究方向為快速偵測、基因分型與定量分析，探討分子流行病學與親緣關係，瞭解病毒基因型變動及演化情形，提供預防策略的參考。

疾病與基因相關研究( 國科會計畫：馬偕兒童感染科紀鑫醫師)

重要研究成果為建置生物材料資源保存中心，保存細菌株共36715株、病毒株共24384株，提供醫學研究部、檢驗科、小兒部、感染管制中心和感染科等作為臨床及研究使用，亦提供院外單位如疾管署、三軍總醫院、榮民總醫院、國家衛生研究院和彰化基督教醫院等共同研究用。本實驗室利用保存中心之材料，除了確認菌株流行病學相關參數與抗藥性機轉外，也運用DNA圖譜分析軟體(BioNumerics)進行脈衝式電泳(PFGE)結果之比對與鑑識。病毒研究部份，對於小兒呼吸道融合病毒，分子流行病學之親緣關係和基因序列的演化分析亦有完整之探討。

可抑制生物膜上金黃色葡萄球菌生長之醫療導管 劉昌邦、王威勝、李聰明，新型第M374340號， 中華民國(台灣) 2010/2/21~2019/9/21

留置型導尿管 劉昌邦、施壽全，新型第M421125號， 中華民國(台灣) 2012/1/21~2021/7/4

脈衝式核酸電泳系統
自動恆溫定量清洗裝置
分光光度計
溫度循環加熱器
自動多孔菌株接種器
雜交培養箱
電泳設備
高速冷凍離心機

Huang WS, Wang TY, Liu CP, Chu TP, Wang YL and Chen MJ. Perianal erythematous skin rash for 2 months. ANZ Journal of Surgery 2023; 93(5):1406-1407. (SCIE, SURGERY) (IF: 1.5, Ranking=154/292 =52.8％)

Wu SJ, Liu CP, Lin J and Fan YF. Klebsiella pneumoniae invasive syndrome complicating aortic dissection. Asian Journal of Surgery 2023; 46(11):5292-5293. (SCIE, SURGERY) (IF: 3.5, Ranking=31/292 =10.7％)

Wu YJ, Chang H, Wang NY, Sun FJ, and Liu CP. Clinical and molecular characteristics and risk factors for patients acquiring carbapenemase- producing and non-carbapenemase-producing carbapenem-nonsusceptible-Enterobacterales bacteremia. Journal of Microbiology, Immunology and Infection 2022; 55(6 Pt 2):1229-1238. (SCIE, INFECTIOUS DISEASES) (IF: 4.5, Ranking=23/132 =17.4％)

Chiang TT, Huang TW, Sun JR, Kuo SC, Cheng A, Liu CP, Liu YM, Yang YS, Chen TL, Lee YT, Wang YC. Biofilm formation is not an independent risk factor for mortality in patients with Acinetobacter baumannii bacteremia. Frontiers in Cellular and Infection Microbiology 2022; 16;12:964539. (SCIE, MICROBIOLOGY) (IF: 4.6, Ranking=37/166 =23.0％)

Liu CP, Leung CH, Kuo CF, Yeh HI. Strategies for Minimizing intra-Hospital Transmission of COVID-19 among Health Care Workers in a Hospital Setting during a COVID-19 Pandemic. International Journal of Gerontology 2022; 16:186-190. (SCIE, GERIATRICS & GERONTOLOGY) (IF: 0.3, Ranking=73/74 =98.6％)

Lee YT, Huang TW, Liu IF, Kuo SC, Yang YS, Lin PY, Liu CP, Liu YM, Chen TL, Wang FD, and Wang YC. The prediction values of carbapenemase detection methods and carbapenem susceptibility testing for clinical outcomes of patients with Acinetobacter bacteremia under carbapenem treatment. Journal of Microbiology, Immunology and Infection 2022; 55(2):257-265. (SCIE, INFECTIOUS DISEASES) (IF: 4.5, Ranking=23/132 =17.4％)

Chang FC, Liu CP, Sun FJ, and Lin CC. Optimizing laboratory workflow for the diagnosis of Clostridiodes difficile infection in a medical center in Northern Taiwan. Journal of Microbiology, Immunology and Infection 2021; 54(2):284-289. (SCIE, INFECTIOUS DISEASES) (IF: 4.5, Ranking=23/132 =17.4％)

Chin CY, Liu CP, and Wang CL. Evolving public behavior and attitudes towards COVID-19 and face masks in Taiwan: A social media study. PLoS One 2021; 20;16(5):e0251845. (SCIE, MULTIDISCIPLINARY SCIENCES) (IF: 2.9, Ranking=32/134 =23.9％)

Chang TL, Huang TW, Wang YX, Liu CP, Kirby R, Chu CM, and Huang CH. An Actinobacterial Isolate, Streptomyces sp. YX44, Produces Broad-Spectrum Antibiotics That Strongly Inhibit Staphylococcus aureus. Microorganisms 2021; 18;9(3):630. (SCIE, MICROBIOLOGY) (IF: 4.1, Ranking=49/161 =30.4％) 

Kang FY, How CK, Wang YC, Cheng A, Yang YS, Kuo SC, Liu CP, Liu YM, Chen TL and Lee YT. Influence of severity of infection on the effect of appropriate antimicrobial therapy for Acinetobacter baumannii bacteremic pneumonia. Antimicrobial Resistance and Infection Control 2020; 29;9(1):160. (SCIE, PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH) (IF: 4.8, Ranking=40/408 =9.8％)